Cochlear Aqueduct Flow Resistance Depends on Round Window Membrane Position in Guinea Pigs
نویسندگان
چکیده
منابع مشابه
Quantitative anatomy of the round window and cochlear aqueduct in guinea pigs.
In order to analyze the entry of solutes through the round window membrane, a quantitative description of round window anatomy in relationship to scala tympani is required. High-resolution magnetic resonance microscopy was used to visualize the fluid spaces and tissues of the inner ear in three dimensions in isolated, fixed specimens from guinea pigs. Each specimen was represented as consecutiv...
متن کاملIntratympanic and Round-Window Drug Therapy: Effect on Cochlear Tinnitus.
Tinnitus is a common symptom for which few existing therapeutic approaches can produce reliable reduction or elimination. Chemical perfusion involves the delivery of medication directly into the inner ear via the round-window membrane. This report discusses the use of dexamethasone or gentamicin in 20 individuals who had inner ear diseases in which disturbing cochlear tinnitus was one of the sy...
متن کاملProtein transduction therapy into cochleae via the round window niche in guinea pigs
Cell-penetrating peptides (CPPs) are short sequences of amino acids that facilitate the penetration of conjugated cargoes across mammalian cell membranes, and as such, they may provide a safe and effective method for drug delivery to the inner ear. Simple polyarginine peptides have been shown to induce significantly higher cell penetration rates among CPPs. Herein, we show that a peptide consis...
متن کاملDifferent Effects of Propofol and Isoflurane on Cochlear Blood Flow and Hearing Function in Guinea Pigs
OBJECTIVES To investigate the effects of isoflurane and propofol on mean arterial pressure (MAP), cochlear blood flow (CoBF), distortion-product otoacoustic emission (DPOAE), and the ultrastructure of outer hair cells (OHCs) in guinea pig cochleae. METHODS Forty-eight male guinea pigs were randomly assigned to one of six treatment groups. Groups 1 to 3 were infused (i.v.) with a loading dose ...
متن کاملEffects of pulsatile electrical stimulation of the round window on central hyperactivity after cochlear trauma in guinea pig.
Partial hearing loss induced by acoustic trauma has been shown in animal models to result in an increased spontaneous firing rate in central auditory structures. This so-called hyperactivity has been suggested to be involved in the generation of tinnitus, a phantom auditory sensation. Although there is no universal cure for tinnitus, electrical stimulation of the cochlea, as achieved by a cochl...
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ژورنال
عنوان ژورنال: Journal of the Association for Research in Otolaryngology
سال: 2004
ISSN: 1525-3961,1438-7573
DOI: 10.1007/s10162-004-5001-x